Chronic idiopathic Sweet syndrome: A report of 2 cases

MDS: myelodysplastic syndrome SS: Sweet syndrome SSKI: saturated solution of potassium iodide S weet syndrome (SS) is classified as a neutrophilic dermatosis based on its chief clinicopathologic findings: sudden onset of painful, tender erythematous skin lesions (papules, plaques, and nodules) and a diffuse infiltrate of mature neutrophils in the dermis. The skin eruptions, which most frequently present on the face, neck, trunk, and upper extremities, are generally accompanied by signs of systemic inflammation including pyrexia, malaise, and arthralgia. First-line therapy for SS is systemic corticosteroids, which typically yield immediate relief from pyrexia and rapid resolution of skin lesions. Alternatives include saturated solution of potassium iodide (SSKI), colchicine, dapsone, indomethacin, sulfapyridine, and tumor necrosis factor antagonists. This report discusses 2 women who had SS for a period longer than expected. There were no factors such as malignancy or SS-inducing medication discovered to be the cause of SS in these patients. Both women responded well to treatment with prednisone; however, skin lesions returned immediately upon attempts to taper themedication.We believe that these cases represent a chronic variant of classical SS, which may be considered in patients who have persistent SS-characteristic skin lesions for over 4 months.